The Senegal international went down after just 15 minutes and was replaced by Leroy Sane.
With just 13 days to go until Senegal’s World cup opener against the Netherlands, fears are growing that Mane could miss the tournament.
Sadio Mane limped off just 20 minutes into the game, most likely the Senegaleese international will be ruled out of the world show piece.
Mane led the Senegal national team to the Africa Cup of Nations trophy and was expected to replicate the same feat going into the World Cup.
He is the current African best player, and the injury is a severe blow to the Senegal national team – one of the strong African contenders to Qatar.
Senegal is in Group A of the 2022 World Cup alongside host Qatar, Netherlands, and Ecuador.